Dichloromethane → tert-butyl N-[1-(4-hydroxypiperidin-1-yl)-1-oxopentan-2-yl]carbamate

HRID 962096Notes

Reaction equation

HRID 962096 reaction equation
[B-:1]([F:2])([F:3])([F:4])[F:5].[C:23]([CH3:24])([CH3:25])([CH3:26])[O:27][C:28](=[O:29])[NH:30][CH:31]([C:32](=[O:33])[OH:34])[CH2:35][CH2:36][CH3:37].[Cl:45][CH2:46][Cl:47].[NH:38]1[CH2:39][CH2:40][CH:41]([OH:44])[CH2:42][CH2:43]1.[n:6]1([O:7][C:8]([N:9]([CH3:10])[CH3:11])=[N+:12]([CH3:13])[CH3:14])[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[n:21][n:22]1>>[C:23]([CH3:24])([CH3:25])([CH3:26])[O:27][C:28](=[O:29])[NH:30][CH:31]([C:32](=[O:34])[N:38]1[CH2:39][CH2:40][CH:41]([OH:44])[CH2:42][CH2:43]1)[CH2:35][CH2:36][CH3:37]

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 26255TetrafluoroborateHCID 79341Piperidin-4-olHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 3024332-(((Tert-butoxy)carbonyl)amino)pentanoic acid

Product 1

HCID 67773529tert-butyl N-[1-(4-hydroxypiperidin-1-yl)-1-oxopentan-2-yl]carbamate

Sources & evidence

ORD record
ord-5315531eb3b0428ab24ba0c313d0b142
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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