Dimethylformamide → 5-Fluoro-2-[3-(methylsulfanyl)phenoxy]-N-[trans-4-(2-oxo-1-piperidinyl)cyclohexyl]nicotinamide
Reaction equation
[CH3:34][N:35]([CH3:36])[CH:37]=[O:38].[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](=[O:7])[NH:8][CH:9]1[CH2:10][CH2:11][CH:12]([NH:15][C:16]([c:17]2[c:18]([O:24][c:25]3[cH:26][c:27]([S:31][CH3:32])[cH:28][cH:29][cH:30]3)[n:19][cH:20][c:21]([F:23])[cH:22]2)=[O:33])[CH2:13][CH2:14]1>>[CH2:2]1[CH2:3][CH2:4][CH2:5][C:6](=[O:7])[N:8]1[CH:9]1[CH2:10][CH2:11][CH:12]([NH:15][C:16]([c:17]2[c:18]([O:24][c:25]3[cH:26][c:27]([S:31][CH3:32])[cH:28][cH:29][cH:30]3)[n:19][cH:20][c:21]([F:23])[cH:22]2)=[O:33])[CH2:13][CH2:14]1Participants
3
Sources & evidence
- ORD record
- ord-863c73938d6745179937327ef1d74656
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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