Ethanol → HCID 19084602, compound

HRID 962381Notes

Reaction equation

HRID 962381 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8].OO.C([OH:16])C>C(O)(=O)C>[N:1]1[CH:6]=[CH:5][N+:4]([O-:16])=[CH:3][C:2]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]

Participants

5

Reactant 3

HCID 702EthanolHCID 784Hydrogen PeroxideHCID 81341Ethyl pyrazinecarboxylate

Product 1

HCID 19084602HCID 19084602, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Compound 26--Ethyl pyrazine carboxylate-4-oxide 3.4 g hydrogen peroxide (30%) was added in three portions over a period of 1 hour to a solution of 3.06 g of ethyl pyrazine carboxylate (prepared as above) in 15 ml of glacial acetic acid at 65° C. After stirring for 16 hours another 3.4 g hydrogen peroxide were added and the solution was stirred for 48 additional hours. The volume of the mixture was reduced, 30 ml of ethanol were added and the solution was filtered. The liquid was evaporated and the residue purified on silica gel with toluene/ethyl acetate to give 0.5 g (14.80) of white ethyl pyrazinecarboxylate-4-oxide; m.pt. 128° C.

Workup

  1. additionwere added
  2. filtrationthe solution was filtered
  3. customThe liquid was evaporated
  4. customthe residue purified on silica gel with toluene/ethyl acetate

Sources & evidence

ORD record
ord-e99968f8abc3486c823554cba1f9d5c2
Source dataset
uspto-grants-1998_06
Patent number
US05759956

Reaction notes

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