Diethylphosphite → HCID 19084852, compound

HRID 962394Notes

Reaction equation

HRID 962394 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][C:6](=[O:12])[C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH3:3].[P:13]([O-:20])([O:17][CH2:18][CH3:19])[O:14][CH2:15][CH3:16]>>[CH2:15]([O:14][P:13]([O:17][CH2:18][CH3:19])([C:6]([OH:12])([CH2:5][CH2:4][N:2]([CH3:3])[CH3:1])[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:20])[CH3:16]

Participants

3

Reactant 2

HCID 3780918DiethylphosphiteHCID 19084838HCID 19084838, compound

Product 1

HCID 19084852HCID 19084852, compound

Procedure

A mixture of 8.05 g (0.05 mole) of ethyl 4-(N,N-dimethylamino)-2-oxobutanoate in 31 g (0.225 mole) of diethyl phosphite is stirred at 20°-30° for 3-5 days. The excess diethyl phosphite is removed on a rotary evaporator under high vacuum at a bath temperature of 50°-70° to yield the crude product as a viscous oil. This is purified by chromatography on silica gel using chloroform/methanol as eluant.

Workup

  1. customThe excess diethyl phosphite is removed on a rotary evaporator under high vacuum at a bath temperature of 50°-70°

Sources & evidence

ORD record
ord-4e600e8b3e50491ab5de08b633c13318
Source dataset
uspto-grants-1998_06
Patent number
US05760021

Reaction notes

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