Diethylphosphite → Ethyl 2-Diethoxyphosphinyl-4-(N,N-dimethylamino)-2-hydroxybutanoate

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Reaction Steps

A mixture of 8.05 g (0.05 mole) of ethyl 4-(N,N-dimethylamino)-2-oxobutanoate in 31 g (0.225 mole) of diethyl phosphite is stirred at 20°-30° for 3-5 days. The excess diethyl phosphite is removed on a rotary evaporator under high vacuum at a bath temperature of 50°-70° to yield the crude product as a viscous oil. This is purified by chromatography on silica gel using chloroform/methanol as eluant.

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