Diethylphosphite → HCID 19084759, compound

HRID 962397Notes

Reaction equation

HRID 962397 reaction equation
[O:1]=[C:2]([CH2:8][CH2:9][N:10]1[CH2:14][CH2:13][CH2:12][CH2:11]1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[P:15]([O-:22])([O:19][CH2:20][CH3:21])[O:16][CH2:17][CH3:18]>>[CH2:17]([O:16][P:15]([O:19][CH2:20][CH3:21])([C:2]([OH:1])([CH2:8][CH2:9][N:10]1[CH2:11][CH2:12][CH2:13][CH2:14]1)[C:3]([O:5][CH2:6][CH3:7])=[O:4])=[O:22])[CH3:18]

Participants

3

Reactant 2

HCID 3780918DiethylphosphiteHCID 19084834HCID 19084834, compound

Product 1

HCID 19084759HCID 19084759, compound

Procedure

A mixture of 9.96 g (0.05 mole) of ethyl 2-oxo-4-(1-pyrrolidinyl)butanoate in 31 g (0.225 mole) of diethyl phosphite is stirred at 20°-30° for 3-6 days. The excess diethyl phosphite is removed on a rotary evaporator under high vacuum at a bath temperature of 50°-70° to yield the crude product as a viscous oil. This is purified by chromatography on silica gel using chloroform/methanol as eluant.

Workup

  1. customThe excess diethyl phosphite is removed on a rotary evaporator under high vacuum at a bath temperature of 50°-70°

Sources & evidence

ORD record
ord-2300f6ef0272435fa1e0f1a03e1c751e
Source dataset
uspto-grants-1998_06
Patent number
US05760021

Reaction notes

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