Diethylphosphite → HCID 19084759, compound

Participants

Reaction Steps

A mixture of 9.96 g (0.05 mole) of ethyl 2-oxo-4-(1-pyrrolidinyl)butanoate in 31 g (0.225 mole) of diethyl phosphite is stirred at 20°-30° for 3-6 days. The excess diethyl phosphite is removed on a rotary evaporator under high vacuum at a bath temperature of 50°-70° to yield the crude product as a viscous oil. This is purified by chromatography on silica gel using chloroform/methanol as eluant.

Provenance & Evidence