Diethylphosphite → HCID 19084797, compound

HRID 962398Notes

Reaction equation

HRID 962398 reaction equation
[O:1]=[C:2]([CH2:8][CH2:9][N:10]1[C:14](=[O:15])[C:13]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]2[C:11]1=[O:20])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[P:21]([O-:28])([O:25][CH2:26][CH3:27])[O:22][CH2:23][CH3:24]>>[CH2:23]([O:22][P:21]([O:25][CH2:26][CH3:27])([C:2]([OH:1])([CH2:8][CH2:9][N:10]1[C:14](=[O:15])[C:13]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]2[C:11]1=[O:20])[C:3]([O:5][CH2:6][CH3:7])=[O:4])=[O:28])[CH3:24]

Participants

3

Reactant 2

HCID 3780918DiethylphosphiteHCID 11970376HCID 11970376, compound

Product 1

HCID 19084797HCID 19084797, compound

Procedure

A mixture of 13.76 g (0.05 mole) of ethyl 2-oxo-4-phthalimidobutanoate in 31 g (0.225 mole) of diethyl phosphite is stirred at 20°-30° for several days. The excess diethyl phosphite is removed on a rotary evaporator under vacuum at a bath temperature of 50°-70° to give the crude product. This is purified by chromatography on silica gel using chloroform/methanol as eluant.

Workup

  1. customThe excess diethyl phosphite is removed on a rotary evaporator under vacuum at a bath temperature of 50°-70°

Sources & evidence

ORD record
ord-317c943e1403475e99054301cdb12018
Source dataset
uspto-grants-1998_06
Patent number
US05760021

Reaction notes

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