Diethylphosphite → HCID 19084797, compound

Participants

Reaction Steps

A mixture of 13.76 g (0.05 mole) of ethyl 2-oxo-4-phthalimidobutanoate in 31 g (0.225 mole) of diethyl phosphite is stirred at 20°-30° for several days. The excess diethyl phosphite is removed on a rotary evaporator under vacuum at a bath temperature of 50°-70° to give the crude product. This is purified by chromatography on silica gel using chloroform/methanol as eluant.

Provenance & Evidence