HCID 19084735, compound → HCID 178525983, compound

HRID 962409Notes

Reaction equation

HRID 962409 reaction equation
[OH:1][C:2]([P:15]([OH:18])([OH:17])=[O:16])([CH2:6][CH2:7][NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)[C:3]([OH:5])=[O:4]>[Pd].O>[OH:1][C:2]([P:15]([OH:17])([OH:18])=[O:16])([CH2:6][CH2:7][N:8]=[C:9]1[CH2:14][CH2:13][CH2:12][CH2:11][NH:10]1)[C:3]([OH:5])=[O:4]

Participants

4

Reactant 1

HCID 19084735HCID 19084735, compound

Product 1

HCID 178525983HCID 178525983, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

A mixture of 2-Hydroxy-2-phosphono-4-(2-pyridylamino)butanoic acid (1.5 g), 100 ml of distilled water, and 0.5 g of palladium on carbon catalyst is hydrogenated at 40 PSI on a Parr apparatus for 2 days. The catalyst is removed by filtration, and the filtrate is evaporated to dryness under vacuum. The resulting crude product is purified by recrystallization from water/ethanol to yield 2-hydroxy-2-phosphono-4-((2-piperidinylidene)amino)butanoic acid.

Workup

  1. customThe catalyst is removed by filtration
  2. customthe filtrate is evaporated to dryness under vacuum
  3. customThe resulting crude product is purified by recrystallization from water/ethanol

Sources & evidence

ORD record
ord-dc249c56b94f4f87ad191c22becb4751
Source dataset
uspto-grants-1998_06
Patent number
US05760021

Reaction notes

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