Diethylphosphite → HCID 19084755, compound

HRID 962411Notes

Reaction equation

HRID 962411 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][NH:6][CH2:7][CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:3].[P:16]([O-:23])([O:20][CH2:21][CH3:22])[O:17][CH2:18][CH3:19]>>[CH2:18]([O:17][P:16]([O:20][CH2:21][CH3:22])([C:9]([OH:15])([CH2:8][CH2:7][NH:6][CH2:5][CH2:4][N:2]([CH3:3])[CH3:1])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[O:23])[CH3:19]

Participants

3

Reactant 2

HCID 3780918DiethylphosphiteHCID 19084750HCID 19084750, compound

Product 1

HCID 19084755HCID 19084755, compound

Procedure

A mixture of 2.15g (0.01 mole) of ethyl 4-(2-(N,N-dimethylamino)ethylamino)-2-oxobutanoate in 6.9 g (0.05 mole) of diethyl phosphite is stirred at 20°-30° for 4 days. The excess diethyl phosphite is removed under vacuum on a rotary evaporator, and the crude product is purified by flash chromatography on silica gel using chloroform/ethanol as eluant.

Workup

  1. customThe excess diethyl phosphite is removed under vacuum on a rotary evaporator
  2. customthe crude product is purified by flash chromatography on silica gel

Sources & evidence

ORD record
ord-f91e3270236b46bfbb93176cad4e9dbc
Source dataset
uspto-grants-1998_06
Patent number
US05760021

Reaction notes

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