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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 962411Generated: November 1, 2026

Diethylphosphite → Ethyl 2-Diethoxyphosphinyl-4-(2-(N,N-dimethylamino)ethylamino)-2-hydroxybutanoate

https://huagongshe.com/reaction/962411

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethylphosphiteHCID 3780918—
Reactantethyl 4-(2-(N,N-dimethylamino)ethylamino)-2-oxobutanoateHCID 19084750—
ProductEthyl 2-Diethoxyphosphinyl-4-(2-(N,N-dimethylamino)ethylamino)-2-hydroxybutanoateHCID 19084755—

Reaction Steps

A mixture of 2.15g (0.01 mole) of ethyl 4-(2-(N,N-dimethylamino)ethylamino)-2-oxobutanoate in 6.9 g (0.05 mole) of diethyl phosphite is stirred at 20°-30° for 4 days. The excess diethyl phosphite is removed under vacuum on a rotary evaporator, and the crude product is purified by flash chromatography on silica gel using chloroform/ethanol as eluant.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05760021
Source datasetuspto-grants-1998_06
ORD IDord-f91e3270236b46bfbb93176cad4e9dbc
Source noteuspto-grants-1998_06