HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-[2-(3-Chlorophenoxy)ethyl]-4-(2-dimethylaminoethyl)piperidine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(2-Bromoethoxy)-3-chlorobenzene | HCID 2507720 | — |
| Reactant | N,N-Dimethyl-2-(piperidin-4-yl)ethanamine dihydrochloride | HCID 19085438 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-[2-(3-Chlorophenoxy)ethyl]-4-(2-dimethylaminoethyl)piperidine dihydrochloride | HCID 19085458 | — |
Reaction Steps
A mixture of 4-(2-dimethylaminoethyl)piperidine dihydrochloride (7.0 g), 2-bromoethyl 3-chlorophenyl ether (7.2 g), triethylamine (12.75 ml) and DMF (50 ml) was heated on a steam bath for 16 hours then worked up as described in Example 16 to give 1-[2-(3-chlorophenoxy)ethyl]-4-(2-dimethylaminoethyl)piperidine dihydrochloride, m.p. 260°-264° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05760035 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-fad6e3f430e54056aa5b45c43ccb0c90 |
| Source note | uspto-grants-1998_06 |