Triethylamine → HCID 19085458, compound

HRID 962445Notes

Reaction equation

HRID 962445 reaction equation
[ClH:1].Cl.[CH3:3][N:4]([CH3:13])[CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[Cl:14][C:15]1[CH:16]=[C:17]([O:21][CH2:22][CH2:23]Br)[CH:18]=[CH:19][CH:20]=1.C(N(CC)CC)C>CN(C=O)C>[ClH:14].[ClH:1].[Cl:14][C:15]1[CH:16]=[C:17]([CH:18]=[CH:19][CH:20]=1)[O:21][CH2:22][CH2:23][N:10]1[CH2:11][CH2:12][CH:7]([CH2:6][CH2:5][N:4]([CH3:3])[CH3:13])[CH2:8][CH2:9]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 25077201-(2-Bromoethoxy)-3-chlorobenzeneHCID 19085438N,N-Dimethyl-2-(piperidin-4-yl)ethanamine dihydrochloride

Product 1

HCID 19085458HCID 19085458, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 4-(2-dimethylaminoethyl)piperidine dihydrochloride (7.0 g), 2-bromoethyl 3-chlorophenyl ether (7.2 g), triethylamine (12.75 ml) and DMF (50 ml) was heated on a steam bath for 16 hours then worked up as described in Example 16 to give 1-[2-(3-chlorophenoxy)ethyl]-4-(2-dimethylaminoethyl)piperidine dihydrochloride, m.p. 260°-264° C.

Workup

  1. temperaturewas heated on a steam bath for 16 hours

Sources & evidence

ORD record
ord-fad6e3f430e54056aa5b45c43ccb0c90
Source dataset
uspto-grants-1998_06
Patent number
US05760035

Reaction notes

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