反应详情

Di-isobutylaluminium hydride (13.2 ml of 1.5M solution in toluene) was added to a mixture of ethyl N-(2-phenoxyethyl)piperidine-3-carboxylate (5.0 g) in dry THF (50 ml) at 0° C. under nitrogen with stirring. The mixture was quenched with water (5 ml) and then treated with saturated Rochelles salt solution. The mixture was stirred at room temperature for 30 minutes and then filtered. The filtrate was separated and the organic layer was washed, dried and evaporated to give N-(2-phenoxyethyl)piperidine-3-carbaldehyde as an oil.

1. customThe mixture was quenched with water (5 ml)
2. additiontreated with saturated Rochelles salt solution
3. stirringThe mixture was stirred at room temperature for 30 minutes
4. filtrationfiltered
5. customThe filtrate was separated
6. washthe organic layer was washed
7. customdried
8. customevaporated