HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl cyanophosphonate → 3-Cyano-N-(1,1-dimethylethyl)androsta-3,5-diene-17-beta-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl cyanophosphonate | HCID 76257 | — |
| Reactant | (8S,9S,10R,13S,14S,17S)-N-tert-butyl-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-17-carboxamide | HCID 475445 | — |
| Product | 3-Cyano-N-(1,1-dimethylethyl)androsta-3,5-diene-17-beta-carboxamide | HCID 67646951 | — |
Reaction Steps
Following a procedure similar to that described in Example 2(c), but using 100 mg of N-t-butyl-3-oxo-4-androstene-17β-carboxamide (prepared as described in Preparation 1), 0.2 ml of diethyl cyanophosphate and 200 mg of a boron trifluoride-diethyl ether complex, 86 mg of the title compound were obtained as a crystalline substance, melting at 198° to 200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05760025 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-26682866b1934f3eb4fbabaebc4f4cd2 |
| Source note | uspto-grants-1998_06 |