反应详情

To a solution of 2-chloroquinoline (15 g) in ethanol (150 ml) was added hydrazine hydrate (40 ml) the resulting solution was heated at reflux for 6 hrs then diluted with water (400 ml) and extracted with diethyl ether (3×200 ml). The collected organic phase was washed with brine (300 ml), dried and concentrated under vacuum to afforg the title compound as a solid (13 g)

1. temperaturewas heated
2. temperatureat reflux for 6 hrs
3. extractionextracted with diethyl ether (3×200 ml)
4. washThe collected organic phase was washed with brine (300 ml)
5. customdried
6. concentrationconcentrated under vacuum