Hydrochloric Acid → HCID 86752687, compound

HRID 962756Notes

Reaction equation

HRID 962756 reaction equation
[C:1]([O:5][C:6]([C:8]1[N:9](C(OC(C)(C)C)=O)[C:10]2[C:15]([C:16]=1[CH:17]([CH:19]1[C:23](=[O:24])[N:22]([C:25](OC(C)(C)C)=O)N(C3C4CC5CC(CC3C5)C4)[CH2:20]1)O)=[C:14]([Cl:42])[CH:13]=[C:12]([Cl:43])[CH:11]=2)=[O:7])(C)(C)C.Cl>C(O)C>[Cl:42][C:14]1[CH:13]=[C:12]([Cl:43])[CH:11]=[C:10]2[C:15]=1[C:16](/[CH:17]=[C:19]1/[C:23](=[O:24])[N:22]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH2:25][CH2:20]/1)=[C:8]([C:6]([O:5][CH3:1])=[O:7])[NH:9]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18694373HCID 18694373, compound

Product 1

HCID 86752687HCID 86752687, compoundYield 215.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

INTERMEDIATE 4 (700 mg) was suspended in ethanol (95 %) (10 ml), hydrochloric acid (10 ml, 6M) was added and the heterogeneous mixture refluxed for 10 h. The suspension was cooled to room temperature and the solid filtered, washed with further portions of 6M hydrochloric acid and finally vacuum dried to yield the title compound (427 mg, ) as a white solid.

Workup

  1. temperaturethe heterogeneous mixture refluxed for 10 h
  2. filtrationthe solid filtered
  3. washwashed with further portions of 6M hydrochloric acid and finally vacuum
  4. customdried

Sources & evidence

ORD record
ord-e323f6a913f046e889e329be3137f57d
Source dataset
uspto-grants-1998_06
Patent number
US05760059

Reaction notes

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