HCID 10471772, compound → HCID 12082818, compound

HRID 962842Notes

Reaction equation

HRID 962842 reaction equation
[OH:1][CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[N:4]=1>C(OCC)(=O)C.O=[Mn]=O>[CH:2]([C:3]1[CH:7]=[C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:5]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[N:4]=1)=[O:1]

Participants

4

Reactant 1

HCID 10471772HCID 10471772, compound

Product 1

HCID 12082818HCID 12082818, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of the alcohol prepared in Example 131, Step 3 (1.1 g, 3.3 mmol) in ethyl acetate (20 mL) was added MnO2 (5 g, 60 mmol) and the mixture stirred at room temperature overnight. The mixture was filtered through Celite and the solution was concentrated to provide the crude aldehyde.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-0a3ef8c2040d416593c92dacce95a18d
Source dataset
uspto-grants-1998_06
Patent number
US05760068

Reaction notes

Loading…