HCID 19085257, compound → HCID 19085172, compound

HRID 963064Notes

Reaction equation

HRID 963064 reaction equation
[Cl:1][C:2]1[CH:41]=[CH:40][CH:39]=[CH:38][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[N:13]1[C:17]([CH3:18])=[N:16][N:15]=[C:14]1[CH2:19][NH:20][C:21](=[O:37])[NH:22][C:23]1[CH:24]=[C:25]([CH2:29][C:30]([O:32]C(C)(C)C)=[O:31])[CH:26]=[CH:27][CH:28]=1)=[O:5]>C(O)=O>[Cl:1][C:2]1[CH:41]=[CH:40][CH:39]=[CH:38][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[N:13]1[C:17]([CH3:18])=[N:16][N:15]=[C:14]1[CH2:19][NH:20][C:21](=[O:37])[NH:22][C:23]1[CH:24]=[C:25]([CH2:29][C:30]([OH:32])=[O:31])[CH:26]=[CH:27][CH:28]=1)=[O:5]

Participants

3

Reactant 1

HCID 19085257HCID 19085257, compound

Product 1

HCID 19085172HCID 19085172, compoundYield 79.2%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

tert-Butyl 3-(3-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethyl)ureido)phenylacetate (0.92 g) was dissolved in formic acid (20 ml), and the solution was allowed to stand at room temperature for one day. The reaction mixture was concentrated, and the obtained residue was recrystallized from ethyl acetate and isopropyl ether to give 0.66 g of 3-(3-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethyl)ureido)phenylacetic acid.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe obtained residue was recrystallized from ethyl acetate and isopropyl ether

Sources & evidence

ORD record
ord-70d900a40a6747d79d04689815ee9b9a
Source dataset
uspto-grants-1998_06
Patent number
US05760032

Reaction notes

Loading…