Sodium Hydroxide → HCID 19085202, compound

HRID 963073Notes

Reaction equation

HRID 963073 reaction equation
[Cl:1][C:2]1[CH:38]=[CH:37][CH:36]=[CH:35][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([C:11]([O:13]CC)=[O:12])[S:8][C:7]=1[N:16]1[C:20]([CH3:21])=[N:19][N:18]=[C:17]1[CH2:22][NH:23][C:24]([C:26]1[NH:27][C:28]2[C:33]([CH:34]=1)=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:25])=[O:5].[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:38]=[CH:37][CH:36]=[CH:35][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([C:11]([OH:13])=[O:12])[S:8][C:7]=1[N:16]1[C:20]([CH3:21])=[N:19][N:18]=[C:17]1[CH2:22][NH:23][C:24]([C:26]1[NH:27][C:28]2[C:33]([CH:34]=1)=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:25])=[O:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86752701HCID 86752701, compound

Product 1

HCID 19085202HCID 19085202, compoundYield 34.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl (3-(2-chlorobenzoyl)-2-(3-(2-indolecarbonylaminomethyl)-5-methyl[1,2,4]triazol-4-yl)thiophen-5-yl)carboxylate (0.16 g) was hydrolyzed using a 2M aqueous sodium hydroxide solution (0.22 ml) and methanol (1 ml) to give 0.053 g of (3-(2-chlorobenzoyl)-2-(3-(2-indolecarbonylaminomethyl)-5-methyl[1,2,4]triazol-4-yl)thiophen-5-yl)carboxylic acid.

Sources & evidence

ORD record
ord-c2feb367472f496ebc2ec88d1d48800d
Source dataset
uspto-grants-1998_06
Patent number
US05760032

Reaction notes

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