HCID 19085144, compound → HCID 19085170, compound

HRID 963084Notes

Reaction equation

HRID 963084 reaction equation
[Cl:1][C:2]1[CH:40]=[CH:39][CH:38]=[CH:37][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[N:13]1[C:17]([CH3:18])=[N:16][N:15]=[C:14]1[CH2:19][NH:20][C:21](=[O:36])[NH:22][C:23]1[CH:24]=[C:25]([CH:33]=[CH:34][CH:35]=1)[C:26]([O:28]C(C)(C)C)=[O:27])=[O:5]>C(O)=O>[Cl:1][C:2]1[CH:40]=[CH:39][CH:38]=[CH:37][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[N:13]1[C:17]([CH3:18])=[N:16][N:15]=[C:14]1[CH2:19][NH:20][C:21](=[O:36])[NH:22][C:23]1[CH:24]=[C:25]([CH:33]=[CH:34][CH:35]=1)[C:26]([OH:28])=[O:27])=[O:5]

Participants

3

Reactant 1

HCID 19085144HCID 19085144, compound

Product 1

HCID 19085170HCID 19085170, compoundYield 80.3%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

tert-Butyl 3-(3-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethyl)ureido)benzoate (800 mg) was dissolved in formic acid (20 ml), and the solution was allowed to stand for one day. The reaction mixture was concentrated, and the obtained crude crystals were recrystallized from isopropyl alcohol to give 580 mg of 3-(3-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethyl)ureido)benzoic acid.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe obtained crude crystals
  3. customwere recrystallized from isopropyl alcohol

Sources & evidence

ORD record
ord-c6d725f1815b4e7ca7fac4f9f76e047e
Source dataset
uspto-grants-1998_06
Patent number
US05760032

Reaction notes

Loading…