HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 19085314, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | benzyl 1H-indole-2-carboxylate | HCID 7723355 | — |
| Reactant | HCID 11499554 | HCID 11499554 | — |
| Reactant | 3-Aminomethyl-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazole ditosylate | HCID 19085095 | — |
| Reactant | HCID 67664386 | HCID 67664386 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 19085314 | HCID 19085314 | — |
Reaction Steps
1-(5-Ethoxycarbonylpentyl)indole-2-carboxylic acid was prepared using benzyl indole-2-carboxylate, DMF, sodium hydride (60% in oil) and ethyl 5-bromohexanoate, and ethyl 6-(2-((4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-yl)methylcarbamoyl)indol-1-yl)hexanoate was synthesized in the same manner as in Example 186 using 3-aminomethyl-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazole di-p-toluenesulfonate, triethylamine and Bop reagent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05760032 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-936009de2d194ea494b3c00867d77ec6 |
| Source note | uspto-grants-1998_06 |