反应详情

1-(5-Ethoxycarbonylpentyl)indole-2-carboxylic acid was prepared using benzyl indole-2-carboxylate, DMF, sodium hydride (60% in oil) and ethyl 5-bromohexanoate, and ethyl 6-(2-((4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-yl)methylcarbamoyl)indol-1-yl)hexanoate was synthesized in the same manner as in Example 186 using 3-aminomethyl-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazole di-p-toluenesulfonate, triethylamine and Bop reagent.