HRID963094

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：F[n+]1c(Cl)cccc1Cl.O=S(=O)([O-])C(F)(F)F

HCID2737311

2,6-Dichloro-1-fluoropyridin-1-ium trifluoromethanesulfonate

C6H3Cl2F4NO3S

结构：CCOC(=O)Cn1c(C(=O)NCc2nnc(C)n2-c2sc(CC)cc2C(=O)c2ccccc2Cl)cc2ccccc21

HCID22439194

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)Cn1c(C(=O)NCc2nnc(C)n2-c2sc(CC)cc2C(=O)c2ccccc2Cl)c(F)c2ccccc21

HCID22439186

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6365

1,1-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

Ethyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)indole-1-acetate is dissolved in dichloroethane, and reacted with 1-fluoro-2,6-dichloropyridiniumtriflate to give ethyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)-3-fluoroindole-1-acetate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5e62e6fff9a94356bbeedc1d67980aef
来源数据集: uspto-grants-1998_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05760032
来源说明: uspto-grants-1998_06

反应 SMILES

[Cl:1][C:2]1[CH:41]=[CH:40][CH:39]=[CH:38][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[N:13]1[C:17]([CH3:18])=[N:16][N:15]=[C:14]1[CH2:19][NH:20][C:21]([C:23]1[N:24]([CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])[C:25]2[C:30]([CH:31]=1)=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])=[O:5].[O-]S(C(F)(F)[F:47])(=O)=O.F[N+]1C(Cl)=CC=CC=1Cl>ClC(Cl)C>[Cl:1][C:2]1[CH:41]=[CH:40][CH:39]=[CH:38][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[N:13]1[C:17]([CH3:18])=[N:16][N:15]=[C:14]1[CH2:19][NH:20][C:21]([C:23]1[N:24]([CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])[C:25]2[C:30]([C:31]=1[F:47])=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])=[O:5]