1-Fluoro-2,6-dichloropyridinium Triflate → HCID 22439186, compound

HRID 963094Notes

Reaction equation

HRID 963094 reaction equation
[Cl:1][C:2]1[CH:41]=[CH:40][CH:39]=[CH:38][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[N:13]1[C:17]([CH3:18])=[N:16][N:15]=[C:14]1[CH2:19][NH:20][C:21]([C:23]1[N:24]([CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])[C:25]2[C:30]([CH:31]=1)=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])=[O:5].[O-]S(C(F)(F)[F:47])(=O)=O.F[N+]1C(Cl)=CC=CC=1Cl>ClC(Cl)C>[Cl:1][C:2]1[CH:41]=[CH:40][CH:39]=[CH:38][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[N:13]1[C:17]([CH3:18])=[N:16][N:15]=[C:14]1[CH2:19][NH:20][C:21]([C:23]1[N:24]([CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])[C:25]2[C:30]([C:31]=1[F:47])=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])=[O:5]

Participants

4

Reactant 2

HCID 27373111-Fluoro-2,6-dichloropyridinium TriflateHCID 22439194Ethyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)indole-1-acetate

Product 1

HCID 22439186HCID 22439186, compound

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

Ethyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)indole-1-acetate is dissolved in dichloroethane, and reacted with 1-fluoro-2,6-dichloropyridiniumtriflate to give ethyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)-3-fluoroindole-1-acetate.

Sources & evidence

ORD record
ord-5e62e6fff9a94356bbeedc1d67980aef
Source dataset
uspto-grants-1998_06
Patent number
US05760032

Reaction notes

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