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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 963094Generated: October 30, 2026

1-Fluoro-2,6-dichloropyridinium Triflate → Ethyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)-3-fluoroindole-1-acetate

https://huagongshe.com/reaction/963094

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Fluoro-2,6-dichloropyridinium TriflateHCID 2737311—
ReactantEthyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)indole-1-acetateHCID 22439194—
Solvent1,1-DichloroethaneHCID 6365—
ProductEthyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)-3-fluoroindole-1-acetateHCID 22439186—

Reaction Steps

Ethyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)indole-1-acetate is dissolved in dichloroethane, and reacted with 1-fluoro-2,6-dichloropyridiniumtriflate to give ethyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)-3-fluoroindole-1-acetate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05760032
Source datasetuspto-grants-1998_06
ORD IDord-5e62e6fff9a94356bbeedc1d67980aef
Source noteuspto-grants-1998_06