反应详情

温度

60 °C

Ethyl 4-(2-chlorophenyl)-6-(2-ethoxycarbonylethyl)-2-ethyl-9-methyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine-6-carboxylate (23 g) was dissolved in ethanol (92 ml). A 4M sodium hydroxide aqueous solution (92 ml) was added and the mixture was stirred at 60° C. for 6 hours. 2M Hydrochloric acid was added to adjust the aqueous solution to pH 2. The solution was extracted with ethyl acetate. The extract was dried over magnesium sulfate, and concentrated. The obtained crystals were taken out, and washed with diisopropyl ether to give 13.5 g of 3-(4-(2-chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepin-6-yl)propionic acid.

1. extractionThe solution was extracted with ethyl acetate
2. dry with materialThe extract was dried over magnesium sulfate
3. concentrationconcentrated
4. washwashed with diisopropyl ether