HCID 86752711, compound → HCID 67662575, compound

HRID 963103Notes

Reaction equation

HRID 963103 reaction equation
[Cl:1][C:2]1[CH:43]=[CH:42][CH:41]=[CH:40][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[N:13]1[C:17]([CH3:18])=[N:16][N:15]=[C:14]1[CH2:19][NH:20][C:21]([CH2:23][N:24]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:26]([C:33]([O:35]C(C)(C)C)=[O:34])=[CH:25]1)=[O:22])=[O:5]>C(O)=O>[Cl:1][C:2]1[CH:43]=[CH:42][CH:41]=[CH:40][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[N:13]1[C:17]([CH3:18])=[N:16][N:15]=[C:14]1[CH2:19][NH:20][C:21]([CH2:23][N:24]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:26]([C:33]([OH:35])=[O:34])=[CH:25]1)=[O:22])=[O:5]

Participants

3

Reactant 1

HCID 86752711HCID 86752711, compound

Product 1

HCID 67662575HCID 67662575, compoundYield 40.5%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

tert-Butyl 1-((4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-yl)methylcarbamoylmethyl)indole-3-carboxylate (500 mg) was dissolved in formic acid (5 ml), and the solution was allowed to stand for one day. The reaction mixture was concentrated, and the obtained residue was crystallized from ethyl acetate to give 184 mg of 1-((4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-yl)methylcarbamoylmethyl)indole-3-carboxylic acid.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe obtained residue was crystallized from ethyl acetate

Sources & evidence

ORD record
ord-c8b6849b20404255860ec11bd88d102e
Source dataset
uspto-grants-1998_06
Patent number
US05760032

Reaction notes

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