1,4-Dioxane hydrochloride → HCID 131720700, compound

HRID 963179Notes

Reaction equation

HRID 963179 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:14]([NH:16][C@H:17]([C:27]([O:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:28])[CH2:18][O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:15])[CH2:3][C:4](=[O:13])[O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[ClH:44].O1CCOCC1>O1CCOCC1>[NH2:1][C@H:2]([C:14]([NH:16][C@H:17]([C:27]([O:29][CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)=[O:28])[CH2:18][O:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:15])[CH2:3][C:4](=[O:13])[O:5][CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1.[ClH:44]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 131720702HCID 131720702, compound

Product 1

HCID 131720700HCID 131720700, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Boc-Asp(OBzl)-Ser(Bzl)-OBzl (42.1 g) was dissolved in dioxane (100 ml), added with a solution of 4M-HCl/dioxane (150 ml) and stirred for 1 hour at room temperature. The reaction mixture was evaporated under reduced pressure and the residue was crystallized from ether to give Asp(OBzl)-Ser(Bzl)-OBzl hydrochloride (33.7 g).

Workup

  1. customThe reaction mixture was evaporated under reduced pressure
  2. customthe residue was crystallized from ether

Sources & evidence

ORD record
ord-a2447e67b2394d2db3cdc78f94c12bcc
Source dataset
uspto-grants-1998_06
Patent number
US05763408

Reaction notes

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