HCID 19081412, compound → HCID 19081382, compound

HRID 963202Notes

Reaction equation

HRID 963202 reaction equation
[NH2:1][C:2]1[C:3](=[O:15])[N:4]([C:11]([CH3:14])([CH3:13])[CH3:12])[N:5]=[CH:6][C:7]=1[N+:8]([O-])=O>[C].[Pd].CO>[NH2:1][C:2]1[C:3](=[O:15])[N:4]([C:11]([CH3:13])([CH3:12])[CH3:14])[N:5]=[CH:6][C:7]=1[NH2:8]

Participants

4

Reactant 1

HCID 19081412HCID 19081412, compound

Product 1

HCID 19081382HCID 19081382, compoundYield 100.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalyst2×HCID 887MethanolSolvent

Procedure

Into 150 ml of an absolute methanol solution of 10.8 g of 4-amino-2-tert-butyl-5-nitropyridazin-3-(2H)-one, 1.1 g of palladium-carbon (containing 5% of Pd) was added in a few times with stirring at room temperature. Then, catalytic reduction was carried out overnight under hydrogen gas pressure. After completion of the reaction, palladium-carbon was separated with celite and washed a few times with absolute methanol. Then, methanol was combined with the filtrate, and the mixture was distilled under reduced pressure to obtain 9.3 g of powdery 4,5-diamino-2-tert-butylpyridazin-3-(2H)-one.

Workup

  1. customwas separated with celite
  2. washwashed a few times with absolute methanol
  3. distillationthe mixture was distilled under reduced pressure

Sources & evidence

ORD record
ord-ff7fb02475da44e8adec67e969686254
Source dataset
uspto-grants-1998_06
Patent number
US05763439

Reaction notes

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