HCID 19081412, compound → HCID 19081382, compound

Participants

Reaction Steps

Into 150 ml of an absolute methanol solution of 10.8 g of 4-amino-2-tert-butyl-5-nitropyridazin-3-(2H)-one, 1.1 g of palladium-carbon (containing 5% of Pd) was added in a few times with stirring at room temperature. Then, catalytic reduction was carried out overnight under hydrogen gas pressure. After completion of the reaction, palladium-carbon was separated with celite and washed a few times with absolute methanol. Then, methanol was combined with the filtrate, and the mixture was distilled under reduced pressure to obtain 9.3 g of powdery 4,5-diamino-2-tert-butylpyridazin-3-(2H)-one.

Provenance & Evidence