1-(3-Methoxypyridin-2-yl)piperazine → 1-[3-(5-Fluorobenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride

HRID 963216Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 963216
[ClH:1].S1[CH2:6][CH:5]([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][N:12]([C:15]3[C:20]([O:21][CH3:22])=[CH:19][CH:18]=[CH:17][N:16]=3)[CH2:11][CH2:10]2)C2C=CC=CC1=2.S(OCCCC1[C:42]2[CH:49]=[C:48]([F:50])[CH:47]=[CH:46][C:43]=2[O:44][CH:45]=1)(C1C=CC(C)=CC=1)(=O)=O.COC1C(N2CCNCC2)=NC=CC=1>>[ClH:1].[F:50][C:48]1[CH:49]=[CH:42][C:43]2[O:44][CH:45]=[C:6]([CH2:5][CH2:7][CH2:8][N:9]3[CH2:14][CH2:13][N:12]([C:15]4[C:20]([O:21][CH3:22])=[CH:19][CH:18]=[CH:17][N:16]=4)[CH2:11][CH2:10]3)[C:46]=2[CH:47]=1

Komponenten

4

Edukt 3

HCID 127904951-(3-Methoxypyridin-2-yl)piperazineHCID 190814335-Fluoro-3-benzo[b]furanpropanol tosylateHCID 190814661-[2-(2,3-Dihydro-benzo[b]thien-3-yl)ethyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride

Produkt 1

HCID 190814511-[3-(5-Fluorobenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride

Versuchsvorschrift

The title compound was prepared (0.93 g, 74%, mp 182°-184° C.) in a manner analogous to the preparation of 1-[2-(2,3-dihydrobenzo[b]thien-3-yl)ethyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride (Example 17) by the reaction of 5-fluoro-3-benzo[b]furanpropanol tosylate with 1-(3-methoxy-2-pyridinyl)piperazine.

Quellen und Nachweise

ORD-Eintrag
ord-c3f0fdbc31bf45a684961329188110c6
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05763444

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