HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Methoxypyridin-2-yl)piperazine → 1-[3-(5-Fluorobenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Methoxypyridin-2-yl)piperazine | HCID 12790495 | — |
| Reactant | 5-Fluoro-3-benzo[b]furanpropanol tosylate | HCID 19081433 | — |
| Reactant | 1-[2-(2,3-Dihydro-benzo[b]thien-3-yl)ethyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride | HCID 19081466 | — |
| Product | 1-[3-(5-Fluorobenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride | HCID 19081451 | — |
Reaction Steps
The title compound was prepared (0.93 g, 74%, mp 182°-184° C.) in a manner analogous to the preparation of 1-[2-(2,3-dihydrobenzo[b]thien-3-yl)ethyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride (Example 17) by the reaction of 5-fluoro-3-benzo[b]furanpropanol tosylate with 1-(3-methoxy-2-pyridinyl)piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763444 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-c3f0fdbc31bf45a684961329188110c6 |
| Source note | uspto-grants-1998_06 |