Propyl p-toluenesulfonate → 1-[3-(5-Methylbenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride

HRID 963219Notes

Reaction equation

HRID 963219 reaction equation
Cl.[Cl:2][C:3]1[CH:28]=[CH:27][C:6]2[O:7][CH:8]=[C:9]([CH2:10][CH2:11][CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:19]4[C:24]([O:25][CH3:26])=[CH:23][CH:22]=[CH:21][N:20]=4)[CH2:15][CH2:14]3)[C:5]=2[CH:4]=1.S(OCCC)([C:32]1C=CC(C)=CC=1)(=O)=O.COC1C(N2CCNCC2)=NC=CC=1>>[ClH:2].[CH3:32][C:3]1[CH:28]=[CH:27][C:6]2[O:7][CH:8]=[C:9]([CH2:10][CH2:11][CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:19]4[C:24]([O:25][CH3:26])=[CH:23][CH:22]=[CH:21][N:20]=4)[CH2:15][CH2:14]3)[C:5]=2[CH:4]=1

Participants

4

Reactant 3

HCID 69035Propyl p-toluenesulfonateHCID 127904951-(3-Methoxypyridin-2-yl)piperazineHCID 190814941-[3-(5-Chlorobenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride

Product 1

HCID 190814851-[3-(5-Methylbenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride

Procedure

The title compound was prepared (0.66 g, 92%, mp 163°-165° C.) in a manner analogous to the preparation of 1-[3-(5-chlorobenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine (Example 25) by the reaction of 5-methyl-3-benzo[b]furan)propanol tosylate with 1-(3-methoxy-2-pyridinyl)piperazine.

Sources & evidence

ORD record
ord-1b090091b2304a45825244750973c446
Source dataset
uspto-grants-1998_06
Patent number
US05763444

Reaction notes

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