1-(3-Methoxypyridin-2-yl)piperazine → 1-[3-(Benzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride
Reaction equation
Cl.[Cl:2][C:3]1[CH:28]=[CH:27][C:6]2[O:7][CH:8]=[C:9]([CH2:10][CH2:11][CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:19]4[C:24]([O:25][CH3:26])=[CH:23][CH:22]=[CH:21][N:20]=4)[CH2:15][CH2:14]3)[C:5]=2[CH:4]=1.S(OCCCC1C2C=CC=CC=2OC=1)(C1C=CC(C)=CC=1)(=O)=O.COC1C(N2CCNCC2)=NC=CC=1>>[ClH:2].[O:7]1[CH:8]=[C:9]([CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][N:16]([C:19]3[C:24]([O:25][CH3:26])=[CH:23][CH:22]=[CH:21][N:20]=3)[CH2:15][CH2:14]2)[C:5]2[CH:4]=[CH:3][CH:28]=[CH:27][C:6]1=2Participants
4
Reactant 3
Product 1
Procedure
The title compound was prepared (0.73 g, 91%, mp 179.5°-182° C.) in a manner analogous to the preparation of 1-[3-(5-chlorobenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine (Example 25) by the reaction of 3-benzo[b]furanpropanol tosylate with 1-(3-methoxy-2-pyridinyl)piperazine.
Sources & evidence
- ORD record
- ord-5828a24f62444aafb203045a973d505c
- Source dataset
- uspto-grants-1998_06
- Patent number
- US05763444
Reaction notes
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