1-(3-Methoxypyridin-2-yl)piperazine → HCID 19081513, compound

HRID 963225Notes

Reaction equation

HRID 963225 reaction equation
[ClH:1].[CH3:2]OC1C=CC2OC=C(CCCN3CCN(C4C(OC)=CN=CN=4)CC3)C=2C=1.S(O[CH2:41][CH2:42][CH2:43][C:44]1[C:45]2[CH:52]=[C:51]([O:53][CH3:54])[CH:50]=[CH:49][C:46]=2[O:47][CH:48]=1)(C1C=CC(C)=CC=1)(=O)=O.[CH3:55][O:56][C:57]1[C:58]([N:63]2[CH2:68][CH2:67][NH:66][CH2:65][CH2:64]2)=[N:59][CH:60]=[CH:61][CH:62]=1>>[ClH:1].[CH3:54][O:53][C:51]1[CH:50]=[CH:49][C:46]2[O:47][CH:48]=[C:44]([CH2:43][CH2:42][CH2:41][N:66]3[CH2:67][CH2:68][N:63]([C:58]4[C:57]([O:56][CH2:55][CH3:2])=[CH:62][CH:61]=[CH:60][N:59]=4)[CH2:64][CH2:65]3)[C:45]=2[CH:52]=1

Participants

4

Reactant 3

HCID 127904951-(3-Methoxypyridin-2-yl)piperazineHCID 190814305-Methoxy-3-benzo[b]furanpropanol tosylateHCID 190814831-[3-(5-Methoxybenzo[b]furan-3-yl)propyl]-4-(5-methoxy-4-pyrimidinyl)piperazine hydrochloride

Product 1

HCID 19081513HCID 19081513, compound

Procedure

The title compound was prepared (0.69 g, 75%, mp 174°-176° C.) in a manner analogous to the preparation of 1-[3-(5-methoxybenzo[b]furan-3-yl)propyl]-4-(5-methoxy-4-pyrimidinyl)piperazine hydrochloride (Example 39) by the reaction of 5-methoxy-3-benzo[b]furanpropanol tosylate with 1-(3-methoxy-2-pyridinyl)piperazine.

Sources & evidence

ORD record
ord-8367917f04db430abc03413c2770d17c
Source dataset
uspto-grants-1998_06
Patent number
US05763444

Reaction notes

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