p-Toluenesulfonate → 1-[3-(Benzo[b]thien-3-yl)propyl]-4-(5-methoxy-4-pyrimidinyl)-2-methylpiperazine hydrochloride

HRID 963227Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 963227
[ClH:1].[S:2]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([O:22][CH3:23])=[CH:20]C=[CH:18][N:17]=3)[CH2:12][CH:11]2[CH3:24])[C:4]2[CH:25]=[CH:26][CH:27]=[CH:28][C:3]1=2.S(C1C=CC(C)=CC=1)([O-])(=O)=O.COC1C(N2CCNC(C)C2)=[N:44]C=NC=1>>[ClH:1].[S:2]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([O:22][CH3:23])=[CH:20][N:44]=[CH:18][N:17]=3)[CH2:12][CH:11]2[CH3:24])[C:4]2[CH:25]=[CH:26][CH:27]=[CH:28][C:3]1=2

Komponenten

4

Edukt 3

HCID 85570p-ToluenesulfonateHCID 150205455-Methoxy-4-(3-methylpiperazin-1-yl)pyrimidineHCID 190814721-[3-(Benzo[b]thien-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)-2-methylpiperazine hydrochloride

Produkt 1

HCID 190815201-[3-(Benzo[b]thien-3-yl)propyl]-4-(5-methoxy-4-pyrimidinyl)-2-methylpiperazine hydrochloride

Versuchsvorschrift

The title compound was prepared (0.80 g, 85%, mp 200°-205° C.) in a manner analogous to the preparation of 1-[3-(benzo[b]thien-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)-2-methylpiperazine hydrochloride (Example 41) by the reaction of 3-benzo[b]thienepropanol tosylate with 1-(5-methoxy-4-pyrimidinyl)-3-methylpiperazine.

Quellen und Nachweise

ORD-Eintrag
ord-39fbc8458da54066b8c61746c8ec53e9
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05763444

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