p-Toluenesulfonate → 1-[2-(Benzo[b]thien-3-yl)ethyl]-4-(3-methoxy-2-pyridinyl)-2-methylpiperazine hydrochloride

HRID 963230Notes

Reaction equation

HRID 963230 reaction equation
[ClH:1].[S:2]1[CH:6]=[C:5]([CH2:7][CH2:8]CN2CCN(C3C(OC)=CC=CN=3)CC2C)[C:4]2[CH:25]=[CH:26][CH:27]=[CH:28][C:3]1=2.S(C1C=CC(C)=CC=1)([O-])(=O)=O.[CH3:40][O:41][C:42]1[C:43]([N:48]2[CH2:53][CH2:52][NH:51][CH:50]([CH3:54])[CH2:49]2)=[N:44][CH:45]=[CH:46][CH:47]=1>>[ClH:1].[S:2]1[CH:6]=[C:5]([CH2:7][CH2:8][N:51]2[CH2:52][CH2:53][N:48]([C:43]3[C:42]([O:41][CH3:40])=[CH:47][CH:46]=[CH:45][N:44]=3)[CH2:49][CH:50]2[CH3:54])[C:4]2[CH:25]=[CH:26][CH:27]=[CH:28][C:3]1=2

Participants

4

Reactant 3

HCID 85570p-ToluenesulfonateHCID 190814721-[3-(Benzo[b]thien-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)-2-methylpiperazine hydrochlorideHCID 190814811-(3-Methoxy-2-pyridinyl)-3-methylpiperazine

Product 1

HCID 190814921-[2-(Benzo[b]thien-3-yl)ethyl]-4-(3-methoxy-2-pyridinyl)-2-methylpiperazine hydrochloride

Procedure

The title compound was prepared (1.39 g, 85%, mp 197°-200° C.) in a manner analogous to the preparation of 1-[3-(benzo[b]thien-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)-2-methylpiperazine hydrochloride (Example 41) by the reaction of 3-benzo[b]thieneethanol tosylate (Example 47) with 1-(3-methoxy-2-pyridinyl)-3-methylpiperazine.

Sources & evidence

ORD record
ord-0aba6f5da7af44d6845fa935bdf913b4
Source dataset
uspto-grants-1998_06
Patent number
US05763444

Reaction notes

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