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p-Toluenesulfonate → 1-[2-(Benzo[b]thien-3-yl)ethyl]-4-(5-methoxy-4-pyrimidinyl)-3-methylpiperazine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonate | HCID 85570 | — |
| 反応物 | 1-[3-(Benzo[b]thien-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)-2-methylpiperazine hydrochloride | HCID 19081472 | — |
| 反応物 | 1-(5-Methoxy-4-pyrimidinyl)-2-methylpiperazine | HCID 19081474 | — |
| 生成物 | 1-[2-(Benzo[b]thien-3-yl)ethyl]-4-(5-methoxy-4-pyrimidinyl)-3-methylpiperazine hydrochloride | HCID 19081498 | — |
反応手順
The title compound was prepared (0.20 g, 24%, mp 140°-144° C.) in a manner analogous to the preparation of 1-[3-(benzo[b]thien-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)-2-methylpiperazine hydrochloride (Example 41) by the reaction of 3-benzo[b]thieneethanol tosylate (Example 47) with 1-(5-methoxy-4-pyrimidinyl)-2-methylpiperazine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05763444 |
| 出典データセット | uspto-grants-1998_06 |
| ORD ID | ord-11c9287b29d44dad9a8e72ae127b0e86 |
| 出典メモ | uspto-grants-1998_06 |