5-Methoxy-4-(piperazin-1-yl)pyrimidine → HCID 19081454, compound

HRID 963234Notes

Reaction equation

HRID 963234 reaction equation
F[C:2]1[CH:27]=[CH:26][C:5]2[S:6][CH:7]=[C:8]([CH2:9][CH2:10][CH2:11][N:12]3[CH2:17][CH2:16][N:15]([C:18]4[C:23]([O:24][CH3:25])=[CH:22][N:21]=[CH:20][N:19]=4)[CH2:14][CH2:13]3)[C:4]=2[CH:3]=1.S(C1C=CC(C)=CC=1)(O)(=O)=O.OCCCC1C2C=C([C:52]([NH2:54])=[O:53])C=CC=2SC=1.COC1C(N2CCNCC2)=NC=NC=1>>[NH2:54][C:52]([C:2]1[CH:27]=[CH:26][C:5]2[S:6][CH:7]=[C:8]([CH2:9][CH2:10][CH2:11][N:12]3[CH2:17][CH2:16][N:15]([C:18]4[C:23]([O:24][CH3:25])=[CH:22][N:21]=[CH:20][N:19]=4)[CH2:14][CH2:13]3)[C:4]=2[CH:3]=1)=[O:53]

Participants

4

Reactant 3

HCID 104201525-Methoxy-4-(piperazin-1-yl)pyrimidineHCID 19081440HCID 19081440, compoundHCID 86752743HCID 86752743, compound

Product 1

HCID 19081454HCID 19081454, compound

Procedure

The title compound was prepared (0.20 g, 37%, mp 169°-170° C.) in a manner analogous to the preparation of 1-[3-(5-fluorobenzo[b]thien-3-yl)propyl]-4-(5-methoxy-4-pyrimidinyl)piperazine (Example 52) by the reaction of 3-(3-hydroxypropyl)benzo[b]thiene-5-carboxamide tosylate with 1-(5-methoxy-4-pyrimidinyl)piperazine.

Sources & evidence

ORD record
ord-68decdf0764440cd8e901717f865dde3
Source dataset
uspto-grants-1998_06
Patent number
US05763444

Reaction notes

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