Benzyl chloroformate → (S)-1-Boc-3-(Cbz-amino-methyl)-piperidine

HRID 963286Notes

Reaction equation

HRID 963286 reaction equation
[OH-].[Na+].[NH2:3][CH2:4][C@@H:5]1[CH2:10][CH2:9][CH2:8][N:7]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:6]1.Cl[C:19]([O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:20]>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.CCCCCC.O>[CH2:22]([O:21][C:19]([NH:3][CH2:4][C@@H:5]1[CH2:10][CH2:9][CH2:8][N:7]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:6]1)=[O:20])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

7

Reactant 3

HCID 10387Benzyl chloroformateHCID 14798Sodium HydroxideHCID 1502022tert-Butyl (3S)-3-(aminomethyl)piperidine-1-carboxylate

Product 1

HCID 45158795(S)-1-Boc-3-(Cbz-amino-methyl)-piperidine

Reagents, catalysts & solvents 3

HCID 94433Tetrabutylammonium hydrogen sulfateCatalystHCID 962WaterSolventHCID 8058HexaneSolvent

Procedure

A)a) 3.7 g of tetrabutylammonium hydrogen sulphate and 100 ml of 1N sodium hydroxide solution are added to a solution of 10.0 g of t-butyl (S)-3-aminomethyl-1-piperidinecarboxylate (Example 6d) in 400 ml of hexane and 100 ml of water. 9.3 ml of benzyl chloroformate are added dropwise to this mixture and the mixture obtained is stirred at room temperature for 3 hours. Subsequently, the organic phase is separated, washed with water, 10% citric acid, water and saturated sodium bicarbonate solution, dried and evaporated. t-Butyl (S)-3-[(1-(benzyloxy)formamido]-methyl]-1-piperidinecarboxylate is obtained.

Workup

  1. customthe mixture obtained
  2. customSubsequently, the organic phase is separated
  3. washwashed with water, 10% citric acid, water and saturated sodium bicarbonate solution
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-019b3b71bc7b4bf2a6fc8d79937d4430
Source dataset
uspto-grants-1998_06
Patent number
US05763436

Reaction notes

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