Triphenylphosphine → {4[(1E)-3-ethoxy-3-oxoprop-1-enyl]-3-methylbenzyl}(triphenyl)phosphonium bromide

Participants

Reaction Steps

A solution of ethyl(2E)-3-[4-(bromomethyl)-2-methylphenyl]prop-2-enoate (intermediate 20, 1.494 g) in toluene (30 ml) was stirred and treated with triphenylphosphine (1.52 g) and then heated at reflux for 2 hours then at 21° C. overnight. More triphenylphosphine (0.5 g) was then added and the reaction heated at reflux for a further 5 hours. The mixture was then allowed to cool and filtered to give the title compound as a white solid.

Provenance & Evidence