反应详情

A solution of ethyl(2E)-3-[4-(bromomethyl)-2-methylphenyl]prop-2-enoate (intermediate 20, 1.494 g) in toluene (30 ml) was stirred and treated with triphenylphosphine (1.52 g) and then heated at reflux for 2 hours then at 21° C. overnight. More triphenylphosphine (0.5 g) was then added and the reaction heated at reflux for a further 5 hours. The mixture was then allowed to cool and filtered to give the title compound as a white solid.

1. temperatureheated
2. temperatureat reflux for 2 hours
3. customat 21° C.
4. customovernight
5. temperaturethe reaction heated
6. temperatureat reflux for a further 5 hours
7. temperatureto cool
8. filtrationfiltered