Piperidine → 1-[4-Amino-5-chloro-2-(3,5-dimethoxybenzyloxy)phenyl]-5-(4-methoxypiperidin-1-yl)pentan-1-one hydrochloride

HRID 963352Notes

Reaction equation

HRID 963352 reaction equation
C([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:18])[CH2:13][CH2:14][CH2:15][CH2:16]Cl)=[C:7]([O:19][CH2:20][C:21]2[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[C:23]([O:29][CH3:30])[CH:22]=2)[CH:6]=1)(=O)C.N1CCCCC1.[CH3:37][O:38][CH:39]1[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]1>>[ClH:11].[NH2:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:18])[CH2:13][CH2:14][CH2:15][CH2:16][N:42]2[CH2:43][CH2:44][CH:39]([O:38][CH3:37])[CH2:40][CH2:41]2)=[C:7]([O:19][CH2:20][C:21]2[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[C:23]([O:29][CH3:30])[CH:22]=2)[CH:6]=1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 776664-MethoxypiperidineHCID 19081830HCID 19081830, compound

Product 1

HCID 190819311-[4-Amino-5-chloro-2-(3,5-dimethoxybenzyloxy)phenyl]-5-(4-methoxypiperidin-1-yl)pentan-1-one hydrochloride

Procedure

Proceeding as in Example 4, Step (c), but replacing 1-(4-acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one with 1-[4-acetylamino-5-chloro-2-(3,5-dimethoxybenzyloxy)phenyl]-5-chloro-pentan-1-one and piperidine with 4-methoxypiperidine, gave 1-[4-amino-5-chloro-2-(3,5-dimethoxybenzyloxy)phenyl]-5-(4-methoxypiperidin-1-yl)pentan-1-one hydrochloride, m.p. 195-196° C.

Sources & evidence

ORD record
ord-88052bda7f0f4b40a5caaf99276ae509
Source dataset
uspto-grants-1998_06
Patent number
US05763458

Reaction notes

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