反应详情

Proceeding as in Example 4, Step (c), but replacing 1-(4-acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one with 1-[4-acetylamino-5-chloro-2-(3,5-dimethoxybenzyloxy)phenyl]-5-chloropentan-1-one and piperidine with 4-(aminocarbonyl)aminopiperidine, gave 1-[4-amino-5-chloro-2-(3,5-dimethoxy-benzyloxy) phenyl]-5-[4-(aminocarbonyl)aminopiperidin-1-yl]pentan-1-one hydrochloride, m.p. 220°-224° C.