Piperidine → 1-[4-Amino-5-chloro-2-(3,5-dimethoxy-benzyloxy) phenyl]-5-[4-(aminocarbonyl)aminopiperidin-1-yl]pentan-1-one hydrochloride

HRID 963354Notes

Reaction equation

HRID 963354 reaction equation
C([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:18])[CH2:13][CH2:14][CH2:15][CH2:16]Cl)=[C:7]([O:19][CH2:20][C:21]2[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[C:23]([O:29][CH3:30])[CH:22]=2)[CH:6]=1)(=O)C.N1CCCCC1.[NH2:37][C:38]([NH:40][CH:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)=[O:39]>>[ClH:11].[NH2:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:18])[CH2:13][CH2:14][CH2:15][CH2:16][N:44]2[CH2:45][CH2:46][CH:41]([NH:40][C:38]([NH2:37])=[O:39])[CH2:42][CH2:43]2)=[C:7]([O:19][CH2:20][C:21]2[CH:22]=[C:23]([O:29][CH3:30])[CH:24]=[C:25]([O:27][CH3:28])[CH:26]=2)[CH:6]=1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 126317214-(Aminocarbonyl)aminopiperidineHCID 19081830HCID 19081830, compound

Product 1

HCID 232026001-[4-Amino-5-chloro-2-(3,5-dimethoxy-benzyloxy) phenyl]-5-[4-(aminocarbonyl)aminopiperidin-1-yl]pentan-1-one hydrochloride

Procedure

Proceeding as in Example 4, Step (c), but replacing 1-(4-acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one with 1-[4-acetylamino-5-chloro-2-(3,5-dimethoxybenzyloxy)phenyl]-5-chloropentan-1-one and piperidine with 4-(aminocarbonyl)aminopiperidine, gave 1-[4-amino-5-chloro-2-(3,5-dimethoxy-benzyloxy) phenyl]-5-[4-(aminocarbonyl)aminopiperidin-1-yl]pentan-1-one hydrochloride, m.p. 220°-224° C.

Sources & evidence

ORD record
ord-190c5760f9e247ec95995b622bd40a35
Source dataset
uspto-grants-1998_06
Patent number
US05763458

Reaction notes

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