Piperidine → 1-[4-Amino-5-chloro-2-(3,5-dimethoxybenzyloxy)phenyl]-5-[4-(methylsulfonyl) aminomethyl-piperidin-1-yl]pentan-1-one hydrochloride

HRID 963355Notes

Reaction equation

C([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:18])[CH2:13][CH2:14][CH2:15][CH2:16]Cl)=[C:7]([O:19][CH2:20][C:21]2[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[C:23]([O:29][CH3:30])[CH:22]=2)[CH:6]=1)(=O)C.N1CCCCC1.[CH3:37][S:38]([NH:41][CH2:42][CH:43]1[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]1)(=[O:40])=[O:39]>>[ClH:11].[NH2:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:18])[CH2:13][CH2:14][CH2:15][CH2:16][N:46]2[CH2:45][CH2:44][CH:43]([CH2:42][NH:41][S:38]([CH3:37])(=[O:39])=[O:40])[CH2:48][CH2:47]2)=[C:7]([O:19][CH2:20][C:21]2[CH:22]=[C:23]([O:29][CH3:30])[CH:24]=[C:25]([O:27][CH3:28])[CH:26]=2)[CH:6]=1

Participants

Reactant 3

HCID 8082Piperidine

HCID 5095908166815-15-2

HCID 19081830HCID 19081830, compound

Product 1

HCID 232025811-[4-Amino-5-chloro-2-(3,5-dimethoxybenzyloxy)phenyl]-5-[4-(methylsulfonyl) aminomethyl-piperidin-1-yl]pentan-1-one hydrochloride

Procedure

Proceeding as in Example 4, Step (c), but replacing 1-(4-acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one with 1-[4-acetylamino-5-chloro-2-(3,5-dimethoxybenzyloxy) phenyl]-5-chloropentan-1-one and piperidine with 4-(methylsulfonyl)aminomethylpiperidine, gave 1-[4-amino-5-chloro-2-(3,5-dimethoxybenzyloxy)phenyl]-5-[4-(methylsulfonyl) aminomethyl-piperidin-1-yl]pentan-1-one hydrochloride, m.p. 211°-213° C.

Sources & evidence

ORD record: ord-303ceb87705c429f826f210d984bb4e5
Source dataset: uspto-grants-1998_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05763458

Reaction notes

Loading…