Piperidine → HCID 23202594, compound

HRID 963356Notes

Reaction equation

HRID 963356 reaction equation
C([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:18])[CH2:13][CH2:14][CH2:15][CH2:16]Cl)=[C:7]([O:19][CH2:20][C:21]2[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[C:23]([O:29][CH3:30])[CH:22]=2)[CH:6]=1)(=O)C.[NH:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1.[CH3:37][S:38]([NH:41][CH2:42][CH2:43]N1CCCCC1)(=[O:40])=[O:39]>>[ClH:11].[NH2:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:18])[CH2:13][CH2:14][CH2:15][CH2:16][N:31]2[CH2:36][CH2:35][CH:34]([CH2:43][CH2:42][NH:41][S:38]([CH3:37])(=[O:40])=[O:39])[CH2:33][CH2:32]2)=[C:7]([O:19][CH2:20][C:21]2[CH:22]=[C:23]([O:29][CH3:30])[CH:24]=[C:25]([O:27][CH3:28])[CH:26]=2)[CH:6]=1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 19081830HCID 19081830, compoundHCID 20351351HCID 20351351, compound

Product 1

HCID 23202594HCID 23202594, compound

Procedure

Proceeding as in Example 4, Step (c), but replacing 1-(4-acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one with 1-[4-acetylamino-5-chloro-2-(3,5-dimethoxybenzyloxy) phenyl]-5-chloropentan-1-one and piperidine with 4[2-(methylsulfonyl)aminoethylpiperidine, gave 1-[4-amino-5-chloro-2-(3,5-dimethoxybenzyloxy) phenyl]-5-{4-[2-(methylsulfonyl)aminoethyl]-piperidin-1-yl}pentan-1-one hydrochloride, m.p. 205°-206° C.

Sources & evidence

ORD record
ord-6e036ca9ded544aa8e08cac8deea140e
Source dataset
uspto-grants-1998_06
Patent number
US05763458

Reaction notes

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