Butyl iodide → HCID 19081916, compound

HRID 963369Notes

Reaction equation

HRID 963369 reaction equation
I[CH2:2][CH2:3][CH2:4][CH3:5].NC1C([Cl:13])=CC(C(=O)CCC2CCNCC2)=C(OC)C=1.[NH2:26][C:27]1[C:32]([Cl:33])=[CH:31][C:30]([C:34](=[O:43])[CH2:35][CH2:36][CH:37]2[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]2)=[C:29]2[O:44][CH2:45][CH2:46][O:47][C:28]=12>>[ClH:13].[NH2:26][C:27]1[C:32]([Cl:33])=[CH:31][C:30]([C:34](=[O:43])[CH2:35][CH2:36][CH:37]2[CH2:42][CH2:41][N:40]([CH2:2][CH2:3][CH2:4][CH3:5])[CH2:39][CH2:38]2)=[C:29]2[O:44][CH2:45][CH2:46][O:47][C:28]=12

Participants

4

Reactant 3

HCID 10962Butyl iodideHCID 9882676HCID 9882676, compoundHCID 9927294HCID 9927294, compound

Product 1

HCID 19081916HCID 19081916, compound

Procedure

Proceeding as in Example 10, but replacing 1-bromopropane with iodobutane and 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(piperidin-4-yl)propan-1-one with 1-(4-amino-5-chloro-2,3-ethylenedioxyphenyl)-3-(piperidin-4-yl)propan-1-one, gave 1-(4-amino-5-chloro-2,3-ethylenedioxyphenyl)-3-[1-(but-1-yl)-piperidin-4-yl]propan-1-one hydrochloride, m.p. 265°-267° C.

Sources & evidence

ORD record
ord-96c6eec3208e4206b748af2119a59357
Source dataset
uspto-grants-1998_06
Patent number
US05763458

Reaction notes

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