3-Methoxybenzyl chloride → HCID 19081926, compound

HRID 963375Notes

Reaction equation

HRID 963375 reaction equation
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9](=[O:23])[CH2:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([C:20]([NH2:22])=[O:21])[CH2:16][CH2:15]2)=[C:4]([O:24][CH3:25])[CH:3]=1.[CH3:26][O:27][C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=1)CCl>>[ClH:8].[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9](=[O:23])[CH2:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([C:20]([NH2:22])=[O:21])[CH2:18][CH2:19]2)=[C:4]([O:24][CH2:25][C:30]2[CH:29]=[C:28]([O:27][CH3:26])[CH:35]=[CH:34][CH:33]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 699943-Methoxybenzyl chlorideHCID 19081936HCID 19081936, compound

Product 1

HCID 19081926HCID 19081926, compound

Procedure

Proceeding as in Example 12, Step (a), but replacing 1-[4-amino-5-chloro-2-methoxyphenyl)-3-{1-[2-(methylsulfonyl)aminoethyl]piperidin-4-yl}propan-1-one with 1-(4-amino-5-chloro-2-methoxyphenyl)-5-(4-aminocarbonylpiperidin-1-yl)-pentan-1-one, and then as in Example 12, Step (b), but replacing 3,5-dimethoxybenzyl chloride with 3-methoxybenzyl chloride, gave 1-[4-amino-5-chloro-2-(5-methoxybenzyloxy)phen yl]-5-(4-aminocarbonylpiperidin-1-yl)-pentan-1-one hydrochloride, m.p. 204°-205° C.

Sources & evidence

ORD record
ord-b26298edeb5b4b0ea49d38341c377e97
Source dataset
uspto-grants-1998_06
Patent number
US05763458

Reaction notes

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