3-Methoxybenzyl chloride → HCID 19081926, compound

Participants

Reaction Steps

Proceeding as in Example 12, Step (a), but replacing 1-[4-amino-5-chloro-2-methoxyphenyl)-3-{1-[2-(methylsulfonyl)aminoethyl]piperidin-4-yl}propan-1-one with 1-(4-amino-5-chloro-2-methoxyphenyl)-5-(4-aminocarbonylpiperidin-1-yl)-pentan-1-one, and then as in Example 12, Step (b), but replacing 3,5-dimethoxybenzyl chloride with 3-methoxybenzyl chloride, gave 1-[4-amino-5-chloro-2-(5-methoxybenzyloxy)phen yl]-5-(4-aminocarbonylpiperidin-1-yl)-pentan-1-one hydrochloride, m.p. 204°-205° C.

Provenance & Evidence